PPP2CA Is a Novel Therapeutic Target in Neuroblastoma Cells That Can Be Activated by the SET Inhibitor OP449
Neuroblastoma (NB) is the most common extracranial solid tumor in childhood and has a poor prognosis Plush in high-risk cases, requiring novel therapies.Pathways that depend on phospho-signaling maintain the aggressiveness of NB.Protein phosphatase 2 (PP2A) with its catalytic subunit PPP2CA is a major phosphatase in cancer cells, including NB.We sh